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USP7 inhibits RELA. 2 / 2
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"These findings suggested that USP7 downregulated by I3MO triggers p53 and p65 degradation and suppresses its downstream signaling transduction.Our previous study indicated that USP7/NEK2/NF-κB pathway activation plays pivotal roles in bortezomib resistance in MM.7 39 Since the stabilization of NEK2 by USP7 is required for the release of p65 into the nucleus, we further investigate whether downregulation of USP7 involved in I3MO efficacy via triggering NEK2 degradation and suppresses its downstream signaling transduction."
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"We also found that overexpression of USP7 strongly suppressed translocation of p65 from the cytoplasm into the nucleus (XREF_FIG)."
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