IndraLab

Statements


OTUB1 binds phospho-SMAD2/3. 3 / 3
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"These observations imply that SMAD4 is not required for the interaction between OTUB1 and phospho-SMAD2/3."

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"The ligand inducible interaction between OTUB1 and phospho-SMAD2/3 indicates that OTUB1 could have a regulatory role in the TGFbeta pathway."

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"We have demonstrated that OTUB1 binds to phospho-SMAD2/3 and E2 ubiquitin conjugating enzymes, thereby inhibiting the polyubiquitylation of SMAD2/3 in vitro."