IndraLab

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ATXN3 activates mutated ATXN3. 2 / 2

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"We then proceeded to assess mutant ataxin-3 detection in crude brain homogenates of 6 months old wildtype and SCA3 transgenic mice overexpressing human mutant ataxin-3."

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"In SCA3, ATXN3 can be SUMOylated at site K166 by SUMO-1, which would enhance mutant ATXN3 stability without affecting aggregate formation."

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IndraLab

Statements

ATXN3 activates mutated ATXN3. 2 / 2

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