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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 activates mutated ATXN3. 2 / 2

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"We then proceeded to assess mutant ataxin-3 detection in crude brain homogenates of 6 months old wildtype and SCA3 transgenic mice overexpressing human mutant ataxin-3."

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"In SCA3, ATXN3 can be SUMOylated at site K166 by SUMO-1, which would enhance mutant ATXN3 stability without affecting aggregate formation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...