IndraLab

Statements

Valproic acid decreases the amount of SCN3A. 3 / 3
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"Epigenetic Downregulation of Scn3a Expression by Valproate : a Possible Role in Its Anticonvulsant Activity."
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"We found that VPA, instead of carbamazepine (CBZ) and lamotrigine (LTG), could significantly downregulate Scn3a expression in mouse Neuro-2a cells."
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"Specifically, VPA has been shown to downregulate the expression of SCN3A, a VGSC subtype, in mouse Neuro-2a cells and reduce Nav1.3 expression in the hippocampus of seizure models (Tan et al., 2017)."
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