IndraLab

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KCNQ1 activates INS. 14 / 14
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"For T2DM, KCNQ1 is produced in the pancreatic islets, and the specific KCNQ1 blocker 293B stimulates insulin secretion XREF_BIBR."
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"In mice, the deletion of the Kcnq1 gene leads to decreased non fasted plasma glucose and insulin concentrations (Boini et al., 2009)."
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"4.2 Potential role of KCNQ1 mediating insulin sensitivity and beta cell function."
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"Expression of KCNQ1 and glucose stimulated insulin secretion in human pancreatic islets."
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"In this study, KCNQ1 rs2237892 SNP was not only associated with a risk for GDM, but also with increased 1h and 2h glucose levels which was consistent with the known association between this SNP and glucose stimulated insulin secretion."
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"KCNQ1 knockout mice have cardiac dysfunctions XREF_BIBR, XREF_BIBR and enhanced systemic insulin sensitivity XREF_BIBR."
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"The risk allele of lead SNP at KCNQ1 is associated with impaired insulin secretion (Unoki et al., 2008; Yasuda et al., 2008) and reduced insulin exocytosis in patients (Rosengren et al., 2012), and Kc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Some pleiotropic KCNQ1 variants in humans can simultaneously increase insulin secretion in the pancreas, reduce serum potassium upon oral glucose challenge, and cause long QT syndrome, putting individuals at risk of sudden, uncontrollable, arrhythmias which may lead to fainting or sudden death 35."
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"12 KCNQ1 is present in adipose tissue and mediates insulin secretion; the mutation of the KCNQ1 gene has been shown to be associated with susceptibility to T2DM 13 and to PTDM."
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"XREF_BIBR For example, mutations in voltage gated potassium channels KCNQ1 and KCNH1, identified as pathogenic in some individuals with long QT syndrome, may also increase secretion of GLP-1, GIP, and insulin, and impair glucagon secretion."
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"Further, the CRISPR and Cas9 mediated deletion of CDKAL1, KCNJ11, and KCNQ1 genes in hESCs disrupted the regulated production of insulin in differentiated beta cells."
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"This case story presents a patient with a gain-of-function mutation KCNQ1 R670K with low glucose-stimulated C-peptide secretion, additionally suggesting involvement of the voltage-gated potassium channel KCNQ1 in glucose-stimulated insulin regulation."
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"The primary aim of the present study was to investigate the putative impact of these KCNQ1 polymorphisms (rs2283228, rs2237892, rs2237895, and rs2237897) on estimates of glucose stimulated insulin release."
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"Inhibition of Kv7.1, as well as KCNQ1 knockdown with siRNA, increased exocytosis and insulin secretion in pancreatic beta-cells."
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