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OTUD3 increases the amount of IREB2. 9 / 9
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"In vivo, after overexpressing OTUD3 and knocking down IRP2, we found that overexpression of OTUD3 promoted IRP2 expression to reduce ferroptosis in hippocampal neurons and improve cerebral I/R injury via the inhibition of the p53/PTGS2 pathway."
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"These evidences suggest that OTUD3 knockout may induce ER stress by reducing the expression of IRP2 protein and up-regulating the contents of iron in neurons."
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"In addition, OTUD3 induced IRP2 expression to protect damaged hippocampal neurons."
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"Overexpression of OTUD3 induced IRP2 expression to reduce ferroptosis in hippocampal neurons and improve cerebral I/R injury via the inhibition of the p53/PTGS2 pathway."
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"Overexpression of an siRNA-resistant WT OTUD3, rather than the C76A mutant, reversed the decrease of IRP2 levels induced by OTUD3 knockdown (Fig. 3d)."
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"These results suggested that the overexpression of OTUD3 induced IRP2 expression to reduce ferroptosis in hippocampal neurons and improve cerebral I/R injury via the inhibition of the p53/PTGS2 pathway."
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"Finally, through in vivo experimental verification, we verified the mechanism of this new pathway in IS; namely, overexpression of OTUD3 induced IRP2 expression to reduce ferroptosis in hippocampal neurons and improve cerebral I/R injury via the inhibition of the p53/PTGS2 pathway.In conclusion, we preliminarily evaluated the effects of the OTUD3/IRP2/p53/PTGS2 pathway on IS and determined whether its potential mechanism of action was related to ferroptosis."
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"OTUD3 induced IRP2 expression to protect damaged hippocampal neurons."
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"OTUD3 promoted IRP2 expression to protect damaged hippocampal neurons."
39415292