IndraLab

Statements

CYLD increases the amount of RIPK1. 3 / 3
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"RIPK1 becomes deubiquitinated by CYLD, which in turn increases the RIPK1 protein level [28,29] ."
25910754
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"In contrast, overexpression of CYLD caused downregulation of RIPK1 in Mel-CV and ME1007 cells, which was nevertheless reversed by the treatment with the proteasome inhibitor MG132 (XREF_FIG), substantiating that downregulation of RIPK1 expression by CYLD is mediated by the proteasomal degradation XREF_BIBR."
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"Furthermore, we demonstrate FMRP to be critically important for regulating key molecules in TNF receptor 1 (TNFR1)-dependent apoptosis and necroptosis including CYLD, c-FLIP S and JNK, which contribute to prolonged RIPK1 expression."
31409605