IndraLab

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USP15 decreases the amount of TBX3. 2 / 2
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"Taken together, reactivated Tbx3 by BRAF plays the same role as in embryonic development, which is to confine the differentiation state.Strikingly, Usp15 removal dramatically abrogated Tbx3 protein expression from E14.5 thyroid without affecting the mRNA level (Fig. 6c and Supplementary Fig. 5b), thus caused similar developmental defects in terms of disorganized folliculogenesis and elevated differentiation factors, such as Tpo, Tg, and Nis (Fig. 7d)."
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"Moreover, USP15 over-expression increased TBX3 levels in a dose-dependent manner, while USP15 knock-down decreased TBX3 expression, its mRNA levels remained relatively stable (Fig. 1e, f and Supplementary Fig. 1d)."
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