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CACNA1A inhibits BAX. 3 / 3
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"To examine the effect of the glutathione detoxification system on the ability of BI-GST to suppress Bax, cells were plated on media supplemented with increasing concentrations of BSO, a compound which[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Unlike the protective effect that BI-GST exerts against prooxidants, which is YAP1-dependent, Bax suppression by BI-GST is YAP1-independent, suggesting an additional facet of BI-GST function which has[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, as the suppression of Bax induced lethality by expression of BI-GST appears very efficient, in fact comparable with inhibition by Bcl-2, and as the expression of BI-GST suppresses effects of Bax on mitochondrial and vacuolar morphology XREF_BIBR, it may not be ruled out that BI-GST actually impairs the ability of Bax to create pores in mitochondrial membranes."
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