IndraLab

Statements

reach
"Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages."
25770182
reach
"Carbon Monoxide Inhibited NLRP3 Inflammasome Activation of AKI in Septic Rats."
26334271
reach
"In our study, CO inhibited the NLRP3 inflammasome activation and decreased the sepsis induced AKI in rats."
26334271
reach
"In the case of the former, CO released by CORM-3 is proposed to inhibit the activation of the NLRP3 inflammasome in cardiac fibroblasts preventing myocardial apoptosis."
30158958
reach
"To block NLRP3 inflammasome and capase-1, PBMCs were pre-incubated for 20 h at 37 °C, and 5% CO 2 with and without 10 μM of OLT1177 (Olatec Therapeutics) or Pralnacasan (VX740 – Vertex, USA)."
35696852
reach
"In terms of decomposition analysis, the aggregate CO 2 intensity effect decreased AII by 23.15 ton/USD and the aggregate structure effect increased AII by 151.51 ton/USD."
39729720
reach
"Previous studies suggested that NLRP3 inflammasome activity is positively regulated by ROS [XREF_BIBR, XREF_BIBR], so CO may inhibit NLRP3 inflammasome activation by decreasing ROS levels in kidney of sepsis induced AKI."
26334271
reach
"CO inhibits the production of IL-1beta induced by inflammasomes and suppresses the activation of the NLRP3 inflammasome in bone marrow derived macrophages; furthermore, CO inhibits mtROS generation, preserves the integrity of mitochondrial membrane, and prevents mtDNA translocation into cytosol."
32973739
reach
"Therefore, CO may also inhibit NLRP3 inflammasome activation by increasing NO levels in sepsis induced AKI."
26334271
reach
"The present study provides a basis for the use of CORM-2 as an effective strategy to protect against sepsis induced AKI, and exogenous CO as released by CORM-2 treatment decreases the oxidative stress and NLRP3 inflammasome activation."
26334271
reach
"Exogenous Carbon Monoxide Decreases Sepsis Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats."
26334271
reach
"CO also inhibits NLRP3 inflammasome activation XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
28378932
reach
"Different CO-releasing molecules or exposure to inhaled CO suppressed NLRP3 inflammasome [69–71], possibly by inducing pyrin production which is its negative regulator [72]."
32908636
reach
"Taken together, these findings indicate that CORM3, and potentially inhalable CO, inhibits activation of the NLRP1 and NLRP3 inflammasomes."
30651220
reach
"Our results suggest that CO negatively regulates NLRP3 inflammasome activation by preventing mitochondrial dysfunction."
25770182
reach
"However, exogenous CO negatively regulates the activation of the NALP3 inflammasome by preventing mitochondrial dysfunction [166], suggesting an anti-inflammatory effect of CO. Exogenous CO also binds to the hemoglobin site on oxidase in macrophage mitochondria, causing a rapid and transient burst of ROS."
36810201
reach
"CO administration by treatment with the CO donor molecule CORM2 (tricarbonyldichlororuthenium (II)) suppressed NLRP3 inflammasome activation in the human monocytic cell line THP-1 [XREF_BIBR], while treatment with the donor CORM3 (tricarbonylchloro (glycinato) ruthenium) inhibited the activation of caspase-1 and production of mature IL-1beta by the human monocytic cell line U937 in response to endoplasmic reticulum stress [XREF_BIBR]."
33266044