IndraLab

Statements

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"CO administration by treatment with the CO donor molecule CORM2 (tricarbonyldichlororuthenium (II)) suppressed NLRP3 inflammasome activation in the human monocytic cell line THP-1 [XREF_BIBR], while treatment with the donor CORM3 (tricarbonylchloro (glycinato) ruthenium) inhibited the activation of caspase-1 and production of mature IL-1beta by the human monocytic cell line U937 in response to endoplasmic reticulum stress [XREF_BIBR]."
33266044
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"Carbon Monoxide Inhibited NLRP3 Inflammasome Activation of AKI in Septic Rats."
26334271
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"Previous studies suggested that NLRP3 inflammasome activity is positively regulated by ROS [XREF_BIBR, XREF_BIBR], so CO may inhibit NLRP3 inflammasome activation by decreasing ROS levels in kidney of sepsis induced AKI."
26334271
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"Therefore, CO may also inhibit NLRP3 inflammasome activation by increasing NO levels in sepsis induced AKI."
26334271
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"Taken together, these findings indicate that CORM3, and potentially inhalable CO, inhibits activation of the NLRP1 and NLRP3 inflammasomes."
30651220
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"Different CO-releasing molecules or exposure to inhaled CO suppressed NLRP3 inflammasome [69–71], possibly by inducing pyrin production which is its negative regulator [72]."
32908636
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"CO inhibits the production of IL-1beta induced by inflammasomes and suppresses the activation of the NLRP3 inflammasome in bone marrow derived macrophages; furthermore, CO inhibits mtROS generation, preserves the integrity of mitochondrial membrane, and prevents mtDNA translocation into cytosol."
32973739
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"Our results suggest that CO negatively regulates NLRP3 inflammasome activation by preventing mitochondrial dysfunction."
25770182
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"In our study, CO inhibited the NLRP3 inflammasome activation and decreased the sepsis induced AKI in rats."
26334271
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"The present study provides a basis for the use of CORM-2 as an effective strategy to protect against sepsis induced AKI, and exogenous CO as released by CORM-2 treatment decreases the oxidative stress and NLRP3 inflammasome activation."
26334271
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"Exogenous Carbon Monoxide Decreases Sepsis Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats."
26334271
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"CO also inhibits NLRP3 inflammasome activation XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
28378932
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"Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages."
25770182
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"In the case of the former, CO released by CORM-3 is proposed to inhibit the activation of the NLRP3 inflammasome in cardiac fibroblasts preventing myocardial apoptosis."
30158958