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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTULIN inhibits GS26575. 2 / 2

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"The deubiquitinase OTULIN negatively regulates M1 linked polyubiquitin signalling by removing the chains conjugated by LUBAC, and OTULIN deficiency causes OTULIN related autoinflammatory syndrome (ORAS) in humans."

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"OTULIN directly binds the LUBAC component HOIP, and knockdown of OTULIN in human cell lines increases M1 linked chains on LUBAC and its substrates."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...