IndraLab

Statements

OTULIN inhibits GS26575. 2 / 2

| 2

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"The deubiquitinase OTULIN negatively regulates M1 linked polyubiquitin signalling by removing the chains conjugated by LUBAC, and OTULIN deficiency causes OTULIN related autoinflammatory syndrome (ORAS) in humans."

32231246

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reach

"OTULIN directly binds the LUBAC component HOIP, and knockdown of OTULIN in human cell lines increases M1 linked chains on LUBAC and its substrates."

27523608

INDRA sources:

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IndraLab

Statements

OTULIN inhibits GS26575. 2 / 2

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