IndraLab

Statements

USP5 activates SNAI2. 7 / 7
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reach
"USP5 promotes epithelial-mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma."
30809294
reach
"Knockdown of USP5 inhibits SLUG deubiquitination and inhibits HCC cells proliferation, metastasis, and invasion, while overexpression of USP5 promotes SLUG stability and EMT in vitro and in vivo."
30809294
reach
"ChIP analysis showed that knockdown of USP5 decreased the binding of SLUG to the promoter of E-cadherin."
30809294
reach
"However, the importance of USP5 promoted SLUG stabilization in EMT must be examined."
30809294
reach
"Consistently, USP5 overexpression prolonged the half-life of SLUG."
30809294
reach
"In previous study, USP5 was found promoting EMT by stabilizing SLUG in hepatocellular carcinoma XREF_BIBR."
33123271
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"USP5 targets the transcription factor SLUG and then induces EMT in hepatocellular carcinoma cells."
32477134