IndraLab

Statements

USP5 activates SNAI2. 12 / 12
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"The findings of the present study indicate that USP5 modulates SLUG protein stability, thereby contributing to the proliferation, invasion and EMT processes in bladder cancer.USPs are implicated in a myriad of pathological processes within malignant tumors, rendering them promising targets for drug development (37)."
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"It was previously reported that USP5 promotes HCC progression by stabilizing SLUG , while USP39 interacts with ZEB1 and regulates HCC proliferation ."
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"In previous study, USP5 was found promoting EMT by stabilizing SLUG in hepatocellular carcinoma XREF_BIBR."
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"Knockdown of USP5 inhibits SLUG deubiquitination and inhibits HCC cells proliferation, metastasis, and invasion, while overexpression of USP5 promotes SLUG stability and EMT in vitro and in vivo."
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"USP5 promotes tumor progression by stabilizing SLUG in bladder cancer."
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"However, the importance of USP5 promoted SLUG stabilization in EMT must be examined."
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"Consistently, USP5 overexpression prolonged the half-life of SLUG."
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"ChIP analysis showed that knockdown of USP5 decreased the binding of SLUG to the promoter of E-cadherin."
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"In hepatocellular carcinoma, USP5 has been reported to promote epithelial-mesenchymal transition (EMT) by stabilizing Snail family zinc finger 2 (SLUG) (13)."
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"Certain studies have reported that USP5 promotes EMT by stabilizing SLUG in hepatocellular carcinoma (12,13)."
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"USP5 targets the transcription factor SLUG and then induces EMT in hepatocellular carcinoma cells."
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"USP5 promotes epithelial-mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma."
30809294