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USP5 activates Notch. 2 / 2

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"Additionally, USP5 enhances Notch/receptor tyrosine kinase (RTK) signaling via NICD stabilization [122], while USP7 and USP12 directly stabilize Notch proteins through deubiquitination [123, 124]."

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"Intriguingly, USP5 has been confirmed to mediate p53 signaling XREF_BIBR, wnt-beta-catenin pathway XREF_BIBR, Type I interferon signaling pathway XREF_BIBR, Notch and RTK signaling pathway XREF_BIBR."

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IndraLab

Statements

USP5 activates Notch. 2 / 2

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