IndraLab

Statements

TP53 binds USP2. 10 / 10
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"In vivo experiments in mice explored the specific role of the USP2-p53 axis in a xenograft tumor model."
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"Although this study provides a preliminary exploration of the role of the USP2-p53 axis-mediated ferroptosis in reversing cisplatin resistance in NSCLC, several limitations persist."
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"Subsequently, COIP was utilized to identify the binding of USP2 and p53, which showed the direct binding between USP2 and p53 (Fig.  xref B)."
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"In our study, USP2 overexpression inhibited p53 ubiquitination and directly interacted with p53."
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"USP2, which is usually suppressed in cisplatin-resistant NSCLC, can directly interact with p53 to promote its stability and nuclear translocation, eventually facilitating ferroptosis xref ."
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"Moreover, USP2 directly bound to p53 and USP2 overexpression stabilized p53 protein by suppressing its ubiquitination."
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"Subsequently, COIP was utilized to identify the binding of USP2 and p53, which showed the direct binding between USP2 and p53 (Fig. 5B)."
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"Our study preliminarily unveils a novel mechanism of DDP resistance in NSCLC, highlighting the critical role of the USP2-p53 axis in regulating cisplatin sensitivity in NSCLC cells."
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"Moreover, USP2 directly bound to p53 and USP2 overexpression stabilized p53 protein by suppressing its ubiquitination."
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"This study revealed that USP2 and p53 were associated with NSCLC cisplatin resistance."
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