IndraLab

Statements

Shikonin inhibits RIPK1. 4 / 4
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"Nonetheless, intravenously injected STP-NG/shikonin inhibited tumor growth in vivo and diminished lung cancer metastasis by enhancing necroptosis via the upregulation of receptor-interacting protein 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Shikonin significantly reduces osteosarcoma metastasis by inducing receptor-interacting protein 1 (RIPK1)- and RIPK3-dependent necroptosis [67]."
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"Shikonin inhibited lung metastases by inducing RIPK1- and RIPK3-dependent necroptosis in osteosarcoma (15), or regulated the production of reactive oxygen species (ROS) through RIPK3 to inhibit tumor cell proliferation and metastasis (16)."
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"The same sensitizing effect by knockdown of RIP1 was obtained in HL60 cells treated with 1.25 muM shikonin for 12 h (XREF_FIG)."
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