IndraLab

Statements

Shikonin inhibits RIPK1. 4 / 4
| 4
reach
"Shikonin significantly reduces osteosarcoma metastasis by inducing receptor-interacting protein 1 (RIPK1)- and RIPK3-dependent necroptosis [67]."
37061535
reach
"Shikonin inhibited lung metastases by inducing RIPK1- and RIPK3-dependent necroptosis in osteosarcoma (15), or regulated the production of reactive oxygen species (ROS) through RIPK3 to inhibit tumor cell proliferation and metastasis (16)."
35814424
reach
"Nonetheless, intravenously injected STP-NG/shikonin inhibited tumor growth in vivo and diminished lung cancer metastasis by enhancing necroptosis via the upregulation of receptor-interacting protein 1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31132429
reach
"The same sensitizing effect by knockdown of RIP1 was obtained in HL60 cells treated with 1.25 muM shikonin for 12 h (XREF_FIG)."
22837689