IndraLab

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ChlA-F increases the amount of USP8. 2 / 2

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"Further studies found that ChlA-F treatment upregulated both the transcription and translation of ubiquitin specific peptidase 8 (USP8) and that the knockdown of USP8 reversed the downregulation of SOX2 resulting from ChlA-F treatment."

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"Therefore, ChlA-F promotes the ubiquitination and protein degradation of SOX2 by inducing HuR expression, whereby it upregulates the expression of USP8 and acts as an E3 ligase (58)."

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IndraLab

Statements

ChlA-F increases the amount of USP8. 2 / 2

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