IndraLab

Statements

COPS6 activates MYC. 8 / 9
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"We have shown that CSN6 increases Myc stability."
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"Furthermore, Fbxw7 deficiency compromised CSN6 shRNA enhanced Myc ubiquitination (XREF_FIG), suggesting that CSN6 mediated Myc stabilization is dependent on Fbxw7."
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"CSN6 mediated Myc stabilization translated to increased Myc transcriptional activity, as evidenced by increasing Myc luciferase reporter gene activity (XREF_FIG) and qRT-PCR for expression of Myc target genes, including CdC25A, Adm-1, and Odc-1 (XREF_FIG)."
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"CSN6 increase Myc stability by reducing Myc ubiquitination."
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"While CSN6 expression increased Myc transcriptional activity, CSN6 knockdown by shRNA reduced Myc transcriptional activity (XREF_FIG)."
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"Noticeably, reduced expression of Csn6 in Emicro-Myc background can also contribute to p53 stabilization in 33% of Emicro-Myc and Csn6 +/- lymphomas when compared with Emicro-Myc and Csn6 +/+, suggesting that both CSN6 mediated p53 downregulation and CSN6 mediated Myc elevation contribute to lymphomagenesis of this system (XREF_FIG)."
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"Thus our study has provided a novel mechanistic answer to how CSN6 can destabilize Fbxw7 and subsequently increase the stability of Myc."
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"Accordingly, CSN6 mediated Myc increases occurred only in HCT116 Fbxw7 +/+ cells (XREF_FIG)."
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