IndraLab

Statements


Wogonin inhibits RELA. 5 / 5
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"Moreover, p65 was reduced by Wogonin in the nucleus of resistant CML cells, and the analysis showed reduction of both Nrf2 and p65 nuclear protein levels to correlate in a 1:1 manner (XREF_FIG and XREF_FIG, also in XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY)."

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"Phosphorylated NF-kappaB p65 was enhanced with the stimulation by wogonin (50 or 100 mug/ml), although total p65 was decreased by 100 mug/ml wogonin."

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"The protein expression of NF-kappaB p65, cyclin D1, and Bcl-2 was decreased in cells treated with wogonin, whereas the protein levels of Bax and cleaved caspase-3 were increased significantly (P < 0.05)."

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"As illustrated in XREF_FIG, data showed Wogonin significantly reduced the effective binding of p65 to the biotin labeled oligonucleotide Nrf2 probe (including kappaB2 site)."

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"Wogonin inhibits the growth of transplantable tumors and down-regulates protein level of p65 and PU.1."