IndraLab

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USP18 activates cell cycle. 6 / 6
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"Consistently, the loss of c-Myc reversed the cell cycle arrest and apoptosis induced by USP18 overexpression in SW1990 cells (XREF_FIG - XREF_FIG)."
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"Overall, these results suggested that USP18 promotes pancreatic cancer cell proliferation by facilitating cell cycle progression and inhibiting cell apoptosis."
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"Moreover , flow cytometry showed that downregulation of USP18 significantly arrested the cell cycle in G1 phase in pancreatic cancer cells ."
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"Moreover, our experimental data revealed that USP18 silencing obviously blocked cell cycle at G1 phase and increased cell apoptosis."
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"Cell cycle analysis showed that USP18 silencing caused a considerable inhibition of cell cycle progression, leading to a selective accumulation of cells in the G1 phase compared with control groups in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP18 promotes PC cell growth by facilitating cell cycle progression."
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