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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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HCN1 binds HCN2 and cooH. 3 / 3

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"Conversely, efficacy would be reduced when the core transmembrane domain of HCN2 interacts with the COOH terminus of HCN1, which explains the smaller than expected shift by cAMP in HCN121 and HCN221."

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"Furthermore, neither CNBDs nor other COOH-terminal domains of HCN1 and HCN2 interacted in yeast two-hybrid assays."

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"Changes in efficacy can account for much of our chimera data if we postulate that cAMP is able to relieve inhibition with a higher than normal efficacy when the core transmembrane domain of HCN1 interacts with the COOH terminus of HCN2."

11524455

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HCN1 binds HCN2 and cooH. 3 / 3

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