IndraLab

Statements

USP9X increases the amount of NRAS. 4 / 4
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"Thus, Usp9x mediated stabilization of Ets-1 (and ERG) regulates NRAS expression."
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"In melanoma, both MEK and BRAF inhibition led to an induction of Ets-1 and NRAS expression that could be blocked by Usp9x inhibition."
28198367
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"These results suggest that Usp9x enhances NRAS expression and in vivo tumour growth, which could be blocked by Usp9x depletion or inhibition."
28198367
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"A previous study reported that USP9X-mediated deubiquitination and stabilization of Ets-1 promoted the expression of the N-RAS oncogene and carcinogenesis in melanoma (56)."
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