IndraLab

Statements

CHEK1 binds USP3. 9 / 9
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sparser
"The interaction between USP3 and CHK1 results in the direct removal of the inhibitory ubiquitin chain at K63, leading to the release of CHK1 from chromatin and subsequent down-regulation of USP3, which enhances gene stability [ xref ]."
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biogrid
No evidence text available
29735693
biogrid
No evidence text available
29735693
biogrid
No evidence text available
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biogrid
No evidence text available
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reach
"32 Additionally, a study has revealed that USP3 interacts with checkpoint kinase 1 (CHK1), counteracting the effects of BTG3‐mediated K63‐linked polyubiquitination of CHK1."
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"However, after phosphorylation of CHK1 at Ser-345 a deubiquitinase, USP3, associates with CHK1 on the chromatin and removes the ubiquitin chain thereby facilitating chromatin dissociation and accessib[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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sparser
"Additionally, a study has revealed that USP3 interacts with checkpoint kinase 1 (CHK1), counteracting the effects of BTG3‐mediated K63‐linked polyubiquitination of CHK1. xref This interaction turns off CHK1 phosphorylation and activation by upstream kinases, facilitating CHK1 release from chromatin to exert its kinase activity on other substrates."
38651282
sparser
"However, after phosphorylation of CHK1 at Ser-345 a deubiquitinase, USP3, associates with CHK1 on the chromatin and removes the ubiquitin chain thereby facilitating chromatin dissociation and accessib[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32991949