IndraLab

Statements

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"Furthermore, Yang et al. found that HCQ reduced the differentiation of Th17 cells and the production of IL-17A in vitro using PBMCs from SLE patients (13)."
35401507
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"In vitro, HCQ inhibited Th17 cell proliferation and differentiation, as well as IL-17 production."
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"In high-fat diet-induced obese mice, HCQ decreased the hepatic levels of macrophage-specific genes [cluster of differentiation 68 (CD68) and arginase 1 (Arg1)] and pro-inflammatory genes (IL-1β, TNF-α and MCP-1)."
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"Hydroxychloroquine (HCQ) is considered to be beneficial in the treatment of obstetrical APS and shown to restore the aPL inhibited invasion and differentiation of trophoblast."
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"9 Previous reports revealed that HCQ inhibits the differentiation of Th-17 cells and decreased the release of IL-17 from the experience of treating systemic lupus erythematosus."
| PMC
eidos
"In particular , hydroxychloroquine can increase the intracellular pH and inhibit lysosomal activity in antigen-presenting cells , reducing T cell activation , differentiation and expression of co-stimulatory proteins ( e.g ."
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"Finally, in antigen presenting cells, hydroxychloroquine prevents antigen processing and subsequently T-cell activation, differentiation, and cytokine production."
| PMC
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"HCQ inhibits osteoblast differentiation and activity."
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"We recently showed that HCQ leads to decreased osteoclast differentiation and activity due to HCQ treatment 25."
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"By preventing antigen processing, hydroxychloroquine reduces T cell activation and differentiation [XREF_BIBR, XREF_BIBR]."
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"The results suggested that HCQ attenuated inflammation by regulating T cells lipid metabolism and T differentiation, which was attributed to promoting the interaction of GRK2 with PI3K in the cytoplasm of T lymphocyte and inhibiting PI3K-AKT axis."
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"Hydroxychloroquine Inhibits the Differentiation of Th17 Cells in Systemic Lupus Erythematosus."
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"Chloroquine and hydroxychloroquine inhibit IL-2 production and then T cell proliferation and differentiation."
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"HCQ (40 and 60 µM) suppressed the differentiation of Th17 and Th1 cells significantly with statistical differences, and 20 µM HCQ suppressed Th17 differentiation similarly (N= 5)."
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"suggested that HCQ might prevent the activation, differentiation and IFN-alpha production by pDC, thereby preventing an efficient response to SARS-CoV-2."
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"Preliminary report by Onodi et al. ( 55 ) suggested that HCQ might prevent the activation , differentiation and IFN-a production by pDC , thereby preventing an efficient response to SARS-CoV-2 ."
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"Figure 3: Hydroxychloroquine (HCQ) suppresses the differentiation and proliferation of T cells."
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"Preliminary report by Onodi et al. ( 55 ) suggested that HCQ might prevent the activation , differentiation and IFN-alpha production by pDC , thereby preventing an efficient response to SARS-CoV-2 ."
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"As the majority of previous studies focused on the innate immunity, only a few in vitro studies showed that HCQ could reduce the activation, proliferation and differentiation of T cells (11–13)."
35401507
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"Finally , in antigen-presenting cells , hydroxychloroquine prevents antigen processing and subsequently T-cell activation , differentiation , and cytokine production ."
| PMC
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"Previous studies have shown that Hydroxychloroquine (HCQ), an essential drug for the treatment of SLE, can inhibit Th17 cell differentiation and production."
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"Moreover , in antigen presenting cells , such as dendritic cells and B cells , HCQ inhibits antigen processing and subsequent MHC class II presentation to T cells , preventing T cell activation , differentiation and expression of co-stimulatory molecules ."
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"Hydroxychloroquine therapy may also reduce B cell activity [129] and Th17 cell differentiation [130,131], while promoting a Th1 to Th2 transition [130] and inhibiting the production of the PICs CCL2 and CXCL10 [132]."
| PMC