IndraLab

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"However, higher concentrations of HCQ (3 mM) tended to inhibit OB differentiation (Fig. 1C), and this inhibition was attenuated by the combination of HCQ and HABP (Fig. 1C) because the HABP also slightly promoted OB differentiation from the BM stromal cells (Fig. 1D)."
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"In SLE patients, hydroxychloroquine treatment increased microRNA-590 and inhibited IL-17 production, gene expression, and Th17 cell differentiation [39] ( Table."
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"Finally , in antigen-presenting cells , hydroxychloroquine prevents antigen processing and subsequently T-cell activation , differentiation , and cytokine production ."
| PMC
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"Preliminary report by Onodi et al. ( 55 ) suggested that HCQ might prevent the activation , differentiation and IFN-alpha production by pDC , thereby preventing an efficient response to SARS-CoV-2 ."
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"In experiments with rodents and PBMC isolated from SLE and HIV patients, HCQ attenuated Th17 differentiation, proliferation, and production of IL-17 while promoting the immunosuppressive effect of Tregs (Piconi et al., 2011; An et al., 2017; Yang et al., 2018; Kowatsch et al., 2023)."
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"Chloroquine and hydroxychloroquine inhibit IL-2 production and then T cell proliferation and differentiation."
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"In particular , hydroxychloroquine can increase the intracellular pH and inhibit lysosomal activity in antigen-presenting cells , reducing T cell activation , differentiation and expression of co-stimulatory proteins ( e.g ."
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"suggested that HCQ might prevent the activation, differentiation and IFN-alpha production by pDC, thereby preventing an efficient response to SARS-CoV-2."
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"By preventing antigen processing, hydroxychloroquine reduces T cell activation and differentiation [XREF_BIBR, XREF_BIBR]."
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"As the majority of previous studies focused on the innate immunity, only a few in vitro studies showed that HCQ could reduce the activation, proliferation and differentiation of T cells (11–13)."
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"Furthermore, Yang et al. found that HCQ reduced the differentiation of Th17 cells and the production of IL-17A in vitro using PBMCs from SLE patients (13)."
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"Figure 3: Hydroxychloroquine (HCQ) suppresses the differentiation and proliferation of T cells."
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"HCQ (40 and 60 µM) suppressed the differentiation of Th17 and Th1 cells significantly with statistical differences, and 20 µM HCQ suppressed Th17 differentiation similarly (N= 5)."
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"The CQ or HCQ dose used for this study was established after a dose–response study and 10 μM CQ or 20 μM HCQ were found to be optimum for the inhibition of arginase activity and enhancement of cell di[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"9 Previous reports revealed that HCQ inhibits the differentiation of Th-17 cells and decreased the release of IL-17 from the experience of treating systemic lupus erythematosus."
| PMC
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"Hydroxychloroquine therapy may also reduce B cell activity [129] and Th17 cell differentiation [130,131], while promoting a Th1 to Th2 transition [130] and inhibiting the production of the PICs CCL2 and CXCL10 [132]."
| PMC
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"Hydroxychloroquine Inhibits the Differentiation of Th17 Cells in Systemic Lupus Erythematosus."
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"Hydroxychloroquine (HCQ) is considered to be beneficial in the treatment of obstetrical APS and shown to restore the aPL inhibited invasion and differentiation of trophoblast."
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"In high-fat diet-induced obese mice, HCQ decreased the hepatic levels of macrophage-specific genes [cluster of differentiation 68 (CD68) and arginase 1 (Arg1)] and pro-inflammatory genes (IL-1β, TNF-α and MCP-1)."
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"Moreover , in antigen presenting cells , such as dendritic cells and B cells , HCQ inhibits antigen processing and subsequent MHC class II presentation to T cells , preventing T cell activation , differentiation and expression of co-stimulatory molecules ."
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"HCQ accumulation in the lysosomes and autophagosomes increases the organelles’ pH and thus inhibits MHC-II antigen presentation and the subsequent differentiation and activation of T and B cells."
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"Finally, in antigen presenting cells, hydroxychloroquine prevents antigen processing and subsequently T-cell activation, differentiation, and cytokine production."
| PMC
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"The results suggested that HCQ attenuated inflammation by regulating T cells lipid metabolism and T differentiation, which was attributed to promoting the interaction of GRK2 with PI3K in the cytoplasm of T lymphocyte and inhibiting PI3K-AKT axis."
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"HCQ can inhibit the differentiation of Tfh cells induced by IL-12, and improve the incidence rate and score of arthritis in model mice [21]."
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"Previous studies have shown that Hydroxychloroquine (HCQ), an essential drug for the treatment of SLE, can inhibit Th17 cell differentiation and production."
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"HCQ increased the proportion of Treg cells and decreased the differentiation of Th17 cells (Additional file 1: Fig. S5A, B)."
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"However, in vitro studies consistently demonstrated that CQ and HCQ inhibited osteogenic differentiation and mineralisation, with the exception that a higher dose of CQ (50 µM) increased mineralisation."
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"A previous study also confirmed that HCQ inhibit differentiation of Th17 cell and production of IL-17 (Yang et al. 2018)."
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"We recently showed that HCQ leads to decreased osteoclast differentiation and activity due to HCQ treatment 25."
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"HCQ inhibits osteoblast differentiation and activity."
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"In vitro, HCQ inhibited Th17 cell proliferation and differentiation, as well as IL-17 production."
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