IndraLab

Statements

OTUD4 activates GSDME. 5 / 5
| 5
reach
"Upregulation of OTUD4 significantly prolonged the half-life of endogenous GSDME, and silencing OTUD4 diminished the degradation half-life of GSDME in NPC cells (Fig. 5I and J)."
36411454
reach
"OTUD4 enhances radiosensitivity in NPC cells by promoting GSDME-dependent pyroptosis."
36411454
reach
"Upregulation of OTUD4 enhances radiosensitivity in NPC cells by promoting GSDME-dependent pyroptosis."
36411454
reach
"Moreover, this study uncovered the first post-translational regulation of GSDME, which is triggered by OTUD4."
36411454
reach
"In addition, we demonstrated that OTUD4 deubiquitinated and stabilized GSDME, enhancing radiosensitivity in NPC by promoting GSDME-dependent pyroptosis."
36411454