IndraLab

Statements

YAP1 binds OTUB2. 20 / 20
3 | 9 8
reach
"For example, poly-SUMOylated OUTB2 induced by EGF/KARS was required for interaction between OTUB2 and YAP/TAZ and subsequently YAP/TAZ stabilization by OTUB2 deubiquitination [16]."
35931679
sparser
"Mechanistically, OTUB2 bound to YAP, decreasing its K48-linked polyubiquitination and inhibiting its subsequent degradation."
39776804
sparser
"Not limited to cancer, the latest research has shown that pantoprazole promotes the degradation of YAP and finally blocks the progress of liver fibrosis by breaking the interaction between OTUB2 and YAP, which indirectly demonstrates that OTUB2 contributes to the progression of liver fibrosis ( xref )."
35309903
sparser
"We then confirmed that OTUB2 interacted with YAP through endogenous Co-IP assays, and the exogenous interaction between OTUB2 and YAP was further confirmed in HEK293T cells transfected with Flag-tagged OTUB2 and HA-tagged YAP (Figure xref B)."
39776804
sparser
"Previous reports have suggested that interactions between OTUB2 and YAP require SUMO modification xref ."
39776804
sparser
"PPZ also disrupted the interaction between the deubiquitinating enzyme OTUB2 and YAP , leading to YAP destabilization and impeding hepatic fibrosis progression ( xref )."
39479501
sparser
"The results revealed that the OTU domain was necessary for the interaction of OTUB2 with YAP, whereas the TBD domain was required for the interaction of YAP with OTUB2 (Figure xref K-L)."
39776804
reach
"OTUB2 can both bind and deubiquitinate and thereby stabilize YAP and TAZ, particularly in cancer cells expressing oncogenic KRAS."
30472188
biogrid
No evidence text available
30472188
sparser
"A previous study revealed a crucial role for SUMOylation in the interaction between OTUB2 and YAP xref ."
39776804
reach
"TIMER database (http://timer.cistrome.org) and the Gene Expression Profiling Interactive Analysis (GEPIA) database (http://gepia.cancer-pku.cn/) were used to search the expression of OTUB2 in esophageal cancer; the GeneMANIA database (http://genemania.org/) was used to search the interaction between OTUB2 and YAP1/TAZ (WWTR1:TAZ also known as WWTR1)."
35850645
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"OTUB2 can bind and stabilize YAP1/TAZ through ubiquitination, and has a certain positive regulatory effect on YAP1/TAZ."
35850645
reach
"OTUB2 interacts with and stabilizes YAP."
39776804
reach
"We then confirmed that OTUB2 interacted with YAP through endogenous Co-IP assays, and the exogenous interaction between OTUB2 and YAP was further confirmed in HEK293T cells transfected with Flag-tagged OTUB2 and HA-tagged YAP (Figure 5B)."
39776804
reach
"In parallel, we separated the nuclear and cytoplasmic proteins from the VSMCs and verified that the OTUB2/YAP interaction was detectable in both the cytoplasmic and the nuclear compartments (Figure 5B and Figure S6A)."
39776804
reach
"Previous reports have suggested that interactions between OTUB2 and YAP require SUMO modification 36."
39776804
reach
"A previous study revealed a crucial role for SUMOylation in the interaction between OTUB2 and YAP 32."
39776804
sparser
"Additionally, we showed that PPZ destabilized YAP by disrupting the interaction between a deubiquitinating enzyme OTUB2 and YAP, and subsequently blocked the progression of hepatic fibrosis."
34465912
biogrid
No evidence text available
30472188
biogrid
No evidence text available
30472188