IndraLab

Statements

USP13 binds MCL1. 31 / 31
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"We further conducted the in vitro immunoprecipitation experiment, the result of which suggested that the interaction between USP13 and MCL1 was direct and independent on MCL1 ubiquitination status (Fig.  xref )."
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"Second, USP13 interacted with MCL1 and decreased MCL1 polyubiquitination in a DUB activity-dependent manner."
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No evidence text available
36535926
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"We first performed co-immunoprecipitation assays to confirm the interaction between USP13 and Mcl-1 by transfecting HEK293T cells with FLAG-USP13 and V5-hMcl-1."
33627786
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"These findings suggest that the USP13-MCL-1 axis represents a potential therapeutic target for AKI management [ xref ]."
41462887
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"USP13 interacts with MCL1 and stabilizes its expression by deubiquitinating MCL1."
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No evidence text available
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No evidence text available
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No evidence text available
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"However, thrombin treatment did not have any notable effect on the interaction between USP13 and MCL1."
39608719
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"USP13 interacts with and deubiquitinates Mcl-1 in cervical cancer cells."
33627786
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"We first performed co-immunoprecipitation assays to confirm the interaction between USP13 and Mcl-1 by transfecting HEK293T cells with FLAG-USP13 and V5-hMcl-1."
33627786
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"Immunoprecipitation with anti-FLAG antibody demonstrated that FLAG-USP13 interacted with over-expressed Mcl-1."
33627786
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"In vitro assays revealed the interaction of USP13 and MCL-1 and USP13 could deubiquitinate and stabilize MCL-1 ( xref ; xref )."
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"Mechanistically, USP13 interacts with and stabilizes MCL1 via deubiquitination."
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"USP13 interacts with and deubiquitinates MCL1."
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"To gain insights into USP13 mediated regulation of MCL1, we tested whether USP13 interacted with MCL1 and functioned as a deubiquitinase."
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"Moreover, the interaction of USP13 and MCL1 occurred between endogenous proteins in A549, HEY and SW-1573 tumor cells."
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"The first hypothesis posits that targeting the USP13-MCL-1 axis can alleviate cisplatin-induced mitochondrial injury in AKI."
41462887
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"However, thrombin treatment did not have any notable effect on the interaction between USP13 and MCL1."
39608719
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"Precision targeting can be achieved through single-cell sequencing, which helps identify pathway-specific activation in distinct renal cells—such as the tubular USP13-MCL-1 axis—and enables more targeted therapeutic interventions [ xref , xref ]."
41462887
biogrid
No evidence text available
33627786
reach
"We further conducted the in vitro immunoprecipitation experiment, the result of which suggested that the interaction between USP13 and MCL1 was direct and independent on MCL1 ubiquitination status."
29335437
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"Therefore, USP13 interacted with and deubiquitinated MCL1 to preserve its protein stability."
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"Therefore, we propose that USP13 is a bona fide deubiquitinase for MCL1, a notion that is further supported by the endogenous interaction and correlative expression of USP13 and MCL1 only at protein levels in clinical tumor samples."
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"Second, USP13 interacted with MCL1 and decreased MCL1 polyubiquitination in a DUB activity dependent manner."
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biogrid
No evidence text available
33627786
biogrid
No evidence text available
34758305
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"However, correlation analysis of RNA sequencing data from TCGA failed to provide evidence that USP13 and MCL1 were associated with each other at the messenger RNA (mRNA) level (Supplementary Fig.  xref ), implying that USP13-mediated regulation of MCL1, if any, might not occur through a transcriptional mechanism."
29335437
sparser
"To gain insights into USP13-mediated regulation of MCL1, we tested whether USP13 interacted with MCL1 and functioned as a deubiquitinase."
29335437
sparser
"Moreover, the interaction of USP13 and MCL1 occurred between endogenous proteins in A549, HEY and SW-1573 tumor cells (Fig.  xref )."
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