IndraLab

Statements

Modified KCNK2 decreases the amount of Cyclin. 2 / 2
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"Although the mechanism by which TREK-1 expression affects cellular functions remains unclear, it is believed, under hypoxic conditions, that the upregulation of TREK-1 expression inhibits the activity of protein kinase A and the expression of cyclin D1 [XREF_BIBR] and decreases neuronal stem cell [XREF_BIBR], astrocyte [XREF_BIBR], and human osteoblasts proliferation [XREF_BIBR, XREF_BIBR]."
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"Overexpression of TREK-1 caused CHO cells arresting at the G1 phase, and significantly decreased the expression of cyclin D1."
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