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USP16 inhibits cellular senescence. 2 / 2

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"In this way, USP16 antagonizes the self-renewal and senescence pathways in multiple tissues."

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"The deubiquitinating enzyme USP16 suppresses self-renewal and senescence pathways in multiple tissues via deubiquitinating H2AK119 and increasing Ink4a locus transcription [XREF_BIBR], while BMI-1 regulates cell cycle, apoptosis and senescence via inhibiting p16 Ink4a and p19 Arf genes encoded by Ink4a [XREF_BIBR, XREF_BIBR]."

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IndraLab

Statements

USP16 inhibits cellular senescence. 2 / 2

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