IndraLab

Statements

Cholesterol inhibits KCNH2. 5 / 6
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"Thus, it follows that progesterone and cholesterol affect Sig-1R actions and reduce hERG channel maturation.Similar results have been obtained for SK3 channels, the small-conductance calcium-activated potassium channels, for which expression of these proteins is regulated by the cellular content of Sig-1R and cholesterol (Gueguinou et al., 2017)."
31068816
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"Extraction of cholesterol with MbetaCD indeed inhibited internalisation of HA-hERG hERG in HeLa cells (XREF_FIG) and also of ERG in ventricular myocytes (XREF_FIG)."
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"A recent study has reported that hERG and KCNQ channels are decreased by cholesterol enrichment via a reduced activity of phosphatidylinositol 4, 5-bisphosphate (PIP2) XREF_BIBR."
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"The human ether-a-go-go related gene (HERG) K channel, which is known to be modulated by PIP , is inhibited by cholesterol enrichment via increased phospholipase C (PLCβ1) expression [16]."
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"These results suggest that cholesterol enrichment inhibits either endogenous MIC current or exogenous HERG current via the membrane PIP 2 depletion by PLC activation."
20015154