IndraLab

Statements

USP9X inhibits FBXW7. 6 / 6
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"USP2215, USP2816 17, USP3718, and OTUD6A19 directly deubiquitinate c-Myc, increasing tumorigenesis, while USP9X indirectly reduces c-Myc by stabilizing its E3 ligase Fbw7, thereby inhibiting CRC growth20.HMGA2 is an architectural transcription factor composed of 109 amino acids and three AT-hooks, which are basic DNA-binding domains."
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"FBW7, the substrate binding component of a ubiquitin ligase complex, targets MCL-1 for degradation by the 26S proteasome, whereas the deubiquitinase USP9X reverses the polyubiquitinating activity of the FBW7 complex [XREF_BIBR]."
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"Besides, USP9X negatively regulated c-Myc by directly stabilizing FBW7 to restore damaged intestinal epithelium and inhibit the development of colitis-associated colon cancer in animal models (140)."
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"Although the E3 ligase Itch was shown to mediate the antitumor effects of USP9X in the pancreas, our data demonstrate that USP9X can prevent intestinal cancer by directly regulating the stability of FBW7 protein."
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"For example, USP9X inhibits the formation of colon tumors by stabilizing FBW7 protein [25]."
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"USP9X antagonized FBW7 ubiquitylation, and Usp9x deletion caused Fbw7 destabilization."
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