IndraLab

Statements

USP9X inhibits FBXW7. 4 / 4
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"FBW7, the substrate binding component of a ubiquitin ligase complex, targets MCL-1 for degradation by the 26S proteasome, whereas the deubiquitinase USP9X reverses the polyubiquitinating activity of the FBW7 complex [XREF_BIBR]."
29899826
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"USP9X antagonized FBW7 ubiquitylation, and Usp9x deletion caused Fbw7 destabilization."
29346117
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"Although the E3 ligase Itch was shown to mediate the antitumor effects of USP9X in the pancreas, our data demonstrate that USP9X can prevent intestinal cancer by directly regulating the stability of FBW7 protein."
29346117
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"Besides, USP9X negatively regulated c-Myc by directly stabilizing FBW7 to restore damaged intestinal epithelium and inhibit the development of colitis-associated colon cancer in animal models (140)."
34956195