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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

MYC increases the amount of USP10. 4 / 4

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"USP10 transcription induced by c-Myc improved the stability of the p14ARF protein [69] ."

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"C-Myc directly binds to the second E-box sequence of the USP10 gene and activates the transcription of USP10 [69]."

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"USP10 also antagonizes c-myc transcription through deubiquitination of SIRT6, a histone deacetylase, and NF-kappaB signaling through deubiquitination of NEMO [XREF_BIBR]."

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"MYC activates USP10 transcription by binding to the second E-box sequence located upstream of the USP10 transcription start site."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

MYC increases the amount of USP10. 4 / 4

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