IndraLab

Statements

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"Therefore, we speculated that the absence of USP21 might inhibit the Th17-type immune response, which exerted a positive effect on the reduction of liver immunopathological damage and might also lead to immune dysfunction in the host."
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"Furthermore, knockout of USP25 in vivo enhances the immune response of mice, possibly leading to higher levels of Th1-stimulating factors, thus promoting Th1 cell differentiation."
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"Furthermore, inhibition of USP25 by AZ1 in a mouse model was shown to suppress inflammation linked to bacterial infections in the intestine and enhance the immune response while inhibiting the activity of USP25 in promoting intestinal cancer (Wang et al, 2020)."
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"In contrast, p38-mediated phosphorylation of USP21 at Ser538 (Ser539 in mouse Usp21) in response to DNA virus infection promotes the binding of USP21 to STING, thus leading to the inactivation of STING and decreased efficiency of antiviral immunity (Chen et al., 2017a)."
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"USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response."
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"Usp22 and Usp21 deletion in T reg cells synergizes to enhance antitumor immunity."
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