IndraLab

Statements

KCNA3 binds BAX. 9 / 10
2 1 | 6
biogrid
No evidence text available
20114030
sparser
"We have also shown that Bax binds to the pore of Kv1.3, subsequently resulting in the inhibition of Kv1.3 activity in isolated mitochondria."
22496117
sparser
"Moreover, the interaction between OMM-localized BAX and Kv1.3 in the IMM causes the inhibition of the latter, with a PT-promoting effect."
33585458
sparser
"In this mechanism, Kv1.3 on the mitochondrial membrane interacts with Bax (Bcl-2 family), triggering apoptosis in the way of toxoid ( xref )."
34093186
sparser
"Strongly relating potassium channels with the regulation of apoptosis, an physical interaction between Bax and Kv1.3 was reported in lymphocytes, which appeared as necessary for Bax-induced apoptosis xref ."
22723988
sparser
"Our results point to a physiologically relevant interaction of Bax with Kv1.3 and further indicate a crucial role of a distinct lysine in determining the proapoptotic character of Bcl2-family proteins."
20885444
biogrid
No evidence text available
20114030
hprd
No evidence text available
18818304
sparser
"To gain insight into the mechanism of Bax-Kv1.3 interaction, we mutated Glu158 of Bcl-x(L) (corresponding to K128 in Bax) to lysine."
20885444