IndraLab

Statements

KCNH2 binds MiRP1. 5 / 5
| 5
reach
"KvLQT1 and minK associate to form the functional slowly activated delayed rectifier potassium channel (I Ks) [12,13] while HERG and MiRP1 associate to form the rapidly activated delayed rectifier pota[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12051962
reach
"While MinK and KvLQT1 complexes recreate the behaviors of I Ks channels, MiRP1 and HERG complexes recapitulate those of I Kr channels."
10219239
reach
"Thus, minK and MiRP1 interaction with HERG are not mediators of regulators of the kinase dependent enhancement of channel synthesis."
22613764
reach
"Second, MiRP1 and HERG complexes and I Kr channels in murine and human cardiac myocytes deactivate 3-fold more rapidly than channels formed only of HERG subunits (Yang et al. 1994; Sanguinetti et al. [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10219239
reach
"Third, MiRP1 and HERG complexes, like I Kr channels in murine atrial and guinea pig ventricular myocytes, are less sensitive to regulation by external K + than HERG channels (Shibasaki 1987; Scamps an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10219239