IndraLab

Statements

KCNH2 binds MiRP1. 5 / 5
| 5
reach
"Third, MiRP1 and HERG complexes, like I Kr channels in murine atrial and guinea pig ventricular myocytes, are less sensitive to regulation by external K + than HERG channels (Shibasaki 1987; Scamps an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10219239
reach
"KvLQT1 and minK associate to form the functional slowly activated delayed rectifier potassium channel (I Ks) [12,13] while HERG and MiRP1 associate to form the rapidly activated delayed rectifier pota[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12051962
reach
"Thus, minK and MiRP1 interaction with HERG are not mediators of regulators of the kinase dependent enhancement of channel synthesis."
22613764
reach
"While MinK and KvLQT1 complexes recreate the behaviors of I Ks channels, MiRP1 and HERG complexes recapitulate those of I Kr channels."
10219239
reach
"Second, MiRP1 and HERG complexes and I Kr channels in murine and human cardiac myocytes deactivate 3-fold more rapidly than channels formed only of HERG subunits (Yang et al. 1994; Sanguinetti et al. [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10219239