IndraLab

Statements


WNK4 activates KCNMA1. 2 / 2
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"Thus, experiments in vivo are required to test whether WNK4 or MAPK can increase BK channel endocytosis in the native renal tubules."

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"These findings suggest that WNK4 WT inhibits Maxi K activity by reducing Maxi K protein at the membrane, but that the inhibition is not due to an increase in clathrin mediated endocytosis of Maxi K, but likely due to enhancing its lysosomal degradation."