IndraLab

Statements

Phosphorylated RB1 is inactive. 3 / 3
2 1 |
bel
"Inactivation of pRb occurs through its gradual phosphorylation by Cdks during the G1 phase of the cell division cycle resulting in the activation of transcription factors that promote cell proliferation and enable transition on to the S phase (see ref. 11 for review)."
18305152
signor
"Cycline/cdk2 blocks myod-induced gene expression through the phosphorylation of rb, preventing rb from binding and transactivating myod, and triggering s phase entry instead of differentiation."
21902831
signor
"This dephosphorylation returns prb to its active, growth suppressive state."
10702384