IndraLab

Statements

UCHL5 activates TCF7. 2 / 2
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"Importantly, we observed that knockdown of Uch37 by Uch37 MO inhibited binding of Tcf7 to target gene promoters (XREF_FIG lane 3)."
28198400
reach
"Fractionation and immunostaining analyses in Xenopus gastrula showed that Uch37 co-localized with Tcf7 in the nucleus where Tcf7 protein exclusively resides despite both cytoplasmic and nuclear localization of Uch37 protein (XREF_SUPPLEMENTARY), raising the possibility that the nuclear pool of Uch37 regulates Tcf7 to activate Wnt signalling."
28198400