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OTUB1 increases the amount of YAP1. 5 / 5
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"MG132 treatment led to an elevation in YAP1 protein levels in control cells, while the impact of MG132 on YAP1 protein levels induced by OTUB1 overexpression was relatively minimal (Figure 4A)."
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"These findings suggest that OTUB1 might modulate YAP1 protein levels through its involvement in the ubiquitin‐proteasome pathway, thus regulating YAP1 stability.To advance our understanding of the role of YAP1 in the phenotypes driven by OTUB1 in HNSCC cells, we assessed the efficacy of YAP1 siRNA in mitigating the cell proliferation and invasion prompted."
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"The immuno-blotting data showed that OTUB1 depletion could decrease YAP protein level in AGS and MKN28 cells (Fig. 2B)."
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"The western blot data showed that OTUB1 over-expression could increase YAP protein level in MKN28 cells (Fig. 2F)."
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"OTUB1 depletion could decrease YAP protein level, while the MG132 treatment could diminish such decrease in YAP protein (Fig. 5C)."
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