IndraLab

Statements

OTULIN activates MAPK cascade. 2 / 2
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reach
"38 However, the notion that OTULIN functions primarily by preventing LUBAC-mediated activation of proinflammatory NF-κB or MAPK signaling has recently been challenged.53 OTULIN supports rather than counteracts LUBAC function by preventing its autoubiquitination."
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eidos
"OTULIN targets Met1-linked Ub and counteracts LUBAC auto-ubiquitination , thereby promoting NF-kappaB activation and MAPK signaling ."
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