IndraLab

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TGFB1 binds LRP1. 3 / 4
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"42 Moreover, LRP1 can bind TGF-beta1 and TGF-beta2 and thereby inhibit cell proliferation and regulate vascular remodeling, respectively."
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"Furthermore, LRP1 and TGFbetaR (V), can directly bind TGFbeta1 XREF_BIBR, as well as enter into a complex with TGFbetaR (I) XREF_BIBR."
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"LRP1 is involved in different cellular processes, such as lipid homeostasis, signal transduction and endocytosis. xref , xref LRP1 also acts as a “protease sink” responsible for cellular uptake of ADAMTS-5 from the extracellular space. xref Moreover, LRP1 can bind TGF-β1 and 2 and thereby inhibit cell proliferation and regulate vascular remodelling, respectively. xref After AngII treatment, LRP1 was less abundant in aortas of Adamts5 Δcat mice."
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