IndraLab

Statements

reach
"USP10 harbors its own single FGDF motif, and over-expression of either USP10 or nsP3 blocks SG assembly following multiple stresses in an FGDF-dependent manner [208] , likely by blocking G3BP1 interac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Timing: ∼3 h Each protein in this multi-component reconstitution system promotes LLPS of G3BP1 in vitro within the appropriate concentration range, including USP10, which inhibits stress granule assembly in cells with a high concentration."
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"The interaction of G3BP1/2 with Caprin1 promotes SG assembly, whereas USP10 inhibits SG assembly [12,13]."
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"To further complicate matters , USP10 impairs SG assembly [ 32 ] , whereas p62 has been implicated in SG clearance [ 19 ] ."
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"USP10 overexpression blocks SG assembly [172,208] , and is hypothesized to act as a capping protein that limits G3BP1/2 interaction valency in the SG network [5,197] ."
38278052