IndraLab

Statements

KCNA5 activates potassium(1+). 7 / 7
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"Kv1.5 mediates the ultrarapid potassium current (I Kur) that controls atrial action potential duration."
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"Moreover, voltage dependent potassium channels are also targeted by miRNAs - KCNA5 as a target of miR-1, KCNQ5 as a target of miR-190 and TASK1 as a target of miR-138."
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"We examined the effects of rosiglitazone on potassium currents mediated by Kv1.5 channels, using a whole-cell patch-clamp technique."
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"Kv1.5, potassium voltage-gated channel, shaker-related subfamily, member 5, underlies the I Kur , ultrarapid delayed rectifier potassium current, which plays a major role among the several outward cur[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The objective of this study was to test the hypothesis that overexpression of KCNA5, which encodes a delayed-rectifier voltage gated K+ (Kv) channel, increases K+ currents and enhances apoptosis."
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"Furthermore, ST induced apoptotic cell shrinkage was significantly accelerated in COS-7 cells and rat PASMC transfected with KCNA5, and blockade of KCNA5 channels with 4-aminopyridine (4-AP) reduced K+ currents through KCNA5 channels and inhibited ST induced apoptosis in KCNA5 transfected COS-7 cells."
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"Overexpression of the human KCNA5 gene increases K+ currents (i.e., K+ efflux or loss), accelerates apoptotic volume decrease (AVD), increases caspase-3 activity, and induces apoptosis."
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