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"Furthermore, MTT assay, colony formation assay, transwell assay and western blot assay results exhibited that overexpression of CDK1 could partially restore the phenotypes of GBM cell proliferation and invasion inhibition caused by OTUD4 knockdown, and the expressions of cell cycle and EMT-related proteins also changed correspondingly (Fig. 6E–H)."
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"Transwell assays demonstrated that OTUD4 knockdown in OE-100 cells significantly reduced lung cancer cell migration and invasion in vitro (Fig. S4C, D)."
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"Hence, we conclude that OTUD4 does affect the activation of the MAPK signaling pathway through the regulation of CDK1, and promote the proliferation and invasion ability of GBM cells."
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"Moreover, we provided in vitro and in vivo evidence that OTUD4 promotes the proliferation and invasion of GBM cells."
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"As shown in Fig. 1 A–D, the knockdown of OTUD4 by its specific shRNAs significantly reduced the migration and invasion abilities of MDA-MB-231 cells."
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"In addition, similar results were also observed in another TNBC cell line HCC1806 ( Fig. 1 A, E–G), which indicates that OTUD4 is pivotal for TNBC cell migration and invasion.To investigate underlying[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, overexpression of OTUD4 notably promoted the proliferation and invasion of LN229 cells (Supplementary Fig. 2G–I, Supplementary Fig. 3E–G)."
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"OTUD4 promotes GBM cell proliferation and invasion."
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