IndraLab

Statements

USP18 activates POU4F1. 5 / 5
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"Silencing USP18 reduced tumor growth in vivo by mediating POU4F1/PRKAA2 axis."
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"USP18 enhanced tumor growth in vivo via mediating POU4F1 and PRKAA2."
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"USP18-mediated POU4F1/PRKAA2 axis was firstly investigated in migration and ferroptosis of LUAD."
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"Furthermore, we found MG132 (a proteasome inhibitor) blocked the protein degradation of POU4F1 caused by silence of USP18 (Supplementary Fig. 1A-B)."
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"Therefore, USP18 could enhance protein stability of POU4F1 through the mediation of de-ubiquitination."
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