IndraLab

Statements

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"Finally, deletion of USP18 inhibited the metastasis of ESCC cells both in vitro and in vivo ."
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"In functional experiments , USP18 knockdown significantly inhibited ESCC invasion and metastasis in vitro ."
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"These data clearly suggested that USP18 promotes the invasion and metastasis of ESCC cells in vitro and in vivo , indicating that USP18 might function as an oncogene for ESCC.As is known, the EMT proc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP18 promotes tumor metastasis in esophageal squamous cell carcinomas via deubiquitinating ZEB1 ."
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"In addition, loss of USP18 suppressed lung cancer cell metastasis by destabilizing the downstream target [14]."
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"Ubiquitin-specific protease 18 (USP18) has been identified to promote lung cancer growth and metastasis by deubiquitinating protein substrates."
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"This study explores if the loss of USP18 reduced lung cancer metastasis."
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"In the tumor, this signaling drives expression of angiogenic and immunosuppressive myeloid chemokines CXCL1, CXCL10, and CCL5; protumor interferon-stimulated genes ISG15 and IFIT3; and oncoprotein USP18, all of which promote tumor growth and metastases, and are selectively blocked by nciLT but not by ciLT."
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"USP18 knock-down reduced lung cancer growth, wound-healing, migration, and invasion versus controls (P < .001) and markedly decreased murine lung cancer metastases (P < .001)."
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"Consistently, the data of RTCA assays also shown that USP18 knockdown significantly suppressed the metastasis ability of TE10 and ECA109 cells ( Fig. 2 E and F)."
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"USP18 could promote tumor metastasis in esophageal squamous cell carcinomas via deubiquitinating ZEB1 [13]."
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"Overall, these findings demonstrated that USP18 promotes ESCC cell's metastasis by regulating the EMT process.Accumulating evidence indicates that ZEB1-mediated EMT plays a critical role in the develo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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