IndraLab

Statements

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"OTUB1 contributes to drug resistance and promotes metastasis."
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"For example, OTUB1 can promote the progression, metastasis and invasion of gastric cancer (GC), prostate cancer and colon cancer (Zhou et al., 2014; Iglesias-Gato et al., 2015; Weng et al., 2016; Zhou et al., 2018)."
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"PSMD14, OTUB1, USP26, and EIF3H, by stabilizing Snail, promote the occurrence of metastasis[24-27]."
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"OTUB1 supported gastric cancer proliferation and metastasis via enhancing Hippo/YAP axis activity."
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"Indeed, OTUB1 has been reported to promote metastasis by facilitating EMT [XREF_BIBR]."
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"A recent report showed that OTUB1 could accelerate metastasis of pancreatic cancer by inhibiting FOXM1 degradation [20]."
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"Recently, OTUB1 was demonstrated to promote the metastasis of esophageal cancer by stabilizing Snail."
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"OTUB1 promotes colorectal cancer metastasis by facilitating EMT and acts as a potential distant metastasis marker and prognostic factor in CRC [39]."
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"Yi Zhou et al. found that OTUB1 was higher expression in colorectal cancer and closely related to the development and prognosis of colorectal cancer, which further confirmed that OTUB1 promotes the me[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, our carried out the in vivo metastasis assay, in which OTUB1 depletion could reduce lung metastasis capacity in MKN28 cells (Fig. 3S, T)."
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"In this sense, OTUB1 may promote colon cancer proliferation, metastasis and recurrence through TGFbeta signal pathway."
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"OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer."
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"OTUB1 was broadly elevated in HCC tissues and promoted the proliferation and metastasis of HCC in vitro and in vivo."
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"Taking together, our present study revealed that OTUB1 played a crucial role in the development of pancreatic cancer, and NDUFS2, identified as a substrate of OTUB1, might be responsible for the observed phenotypes in the absence of OTUB1 in pancreatic cancer.A recent report showed that OTUB1 may accelerate metastasis of pancreatic cancer by inhibiting FOXM1 degradation [20]."
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"OTUB1 promotes CRC metastasis by facilitating EMT and acts as a potential distant metastasis marker and prognostic factor in CRC."
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"These data suggest that OTUB1‐isoform2 promotes ovarian tumour growth and metastasis in vivo.4 DISCUSSION."
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"Honghong Zhou et al. proved that OTUB1 promotes the metastasis and migration of esophageal squamous cell carcinoma through regulating Snail stability [ 36 ]."
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"OTUB1 also promoted the metastasis of CRC cell lines in vitro and in vivo by regulating EMT."
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"In the in vivo metastasis assay, OTUB1 depletion could significantly reduce the lung metastasis, which effect could be partially rescued by YAP over-expression in MKN28 cells (Fig. 4T, U)."
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"There may be a variety of mechanisms involved in OTUB1 promoting the metastasis of colorectal cancer."
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"These results revealed that OTUB1 promoted CRC cell liver metastasis in vivo."
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"OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability."
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"Together, our findings demonstrate that OTUB1 promotes the migration, invasion, and metastasis of CRC cells in vitro and in vivo and acts as a potential metastasis marker and prognostic factor in CRC."
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"Recent research indicates that ETS1, OTUB1 and PTP4A1 could promote OSCC proliferation, invasion, and metastasis (7–9)."
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"OTUB1 knockdown inhibited metastasis and proliferation of GBM cells while promoting apoptosis and cell cycle arrest at the G1 phase in vitro."
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"Overexpression of OTUB1 promoted GBM cell metastasis, proliferation, G1 to S phase transition, and suppressed apoptosis in vitro."
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"Silencing OTUB1 can significantly inhibit cancer status and metastasis, and targeting OTUB1 would be an excellent target for numerous cancer patients."
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"With a tail-vein injection model, the authors showed OTUB1 promotes lung metastasis of esophageal squamous cell carcinoma cells in vivo (Zhou et al., 2018)."
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"In addition, OTUB1 (an OTU family protein) and PSMD14 (a JAMM family protein) promotes metastasis of human esophageal squamous carcinoma by stabilizing Snail [21,22]."
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