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ATXN3 inhibits DNA repair. 2 / 2
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"We propose that this mechanism ensures that ataxin-3 prevents the premature removal of DNA repair proteins only during the early phase of the DSB response and does not interfere with the subsequent timely displacement of DNA repair proteins by RNF4."
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"We propose that the immediate presence of ataxin-3 at DNA lesions prevents premature removal of MDC1 from DSBs and by this means reinforces initiation of DNA damage signaling and DNA repair (Fig XREF_FIG)."
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