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eidos
"We found that downregulation of either YAP or TAZ prevented the EMT that is induced by CYLD downregulation ( Figure 5d ) ."
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"CYLD downregulation or inactivation induced an epithelial to mesenchymal transition of mammary epithelial cells that was dependent on the concomitant activation of the transcription factors Yes associated protein (YAP)/transcriptional coactivator with PDZ binding motif (TAZ) and transforming growth factor beta (TGF) signaling."
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"The Tumor Suppressor CYLD Inhibits Mammary Epithelial to Mesenchymal Transition by the Coordinated Inhibition of YAP and TAZ and TGF Signaling."
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"Reintroduction of CYLD could rescue TGF-β-induced EMT program (Fig. 3F), suggesting the specific role for CYLD in regulating EMT."
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