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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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3',5'-cyclic AMP activates HCN1. 4 / 4

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"HCN2-related I (but not HCN1-related I ) is highly modulated by cAMP which: a) increases I magnitude by increasing HCN2 open probability [54], [55]; b) depolarises V (by ∼15 mV) and c) accelerates I activation [1]."

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"In contrast to HCN2 and HCN4, PEX5R failed to exert any obvious effect on gating and cAMP modulation of HCN1 channels in excised patches."

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"First, cAMP activates homomers of intact bCNG1 with low efficacy, so low efficacy is not in itself an absolute indicator of BD misfolding."

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"Thus, cAMP might produce little or no net shift in the activation range of I h due solely to HCN1 and HCN3."

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3',5'-cyclic AMP activates HCN1. 4 / 4

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