IndraLab

Statements

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"Elevation of the intracellular cAMP concentration by incubation with the adenylate cyclase activator, forskolin (10 micromol/L), and the broad range phosphodiesterase inhibitor, IBMX (100 micromol/L), caused a HERG tail current reduction of 83.2%."
12133532
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"HERG current may be decreased by cAMP dependent activation of PKA; however, a putative direct binding of cAMP to the channel causes opposite effects."
23029432
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"CAMP therefore decreases effective HERG activity through current inhibition and accelerated deactivation kinetics with minimal alteration of voltage dependent activation.To assess whether cAMP was act[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10837251